Some home gardeners like to use hand picking as a nonchemical method for controlling these large insects. However, wear gloves and use caution because these beetles contain a substance called cantharidin. This chemical is an irritant capable of blistering internal and external body tissues exposed to the chemical. On tender human skin, body fluids of adult blister beetles may cause large, erect, watery blisters.
Chemical control of blister beetles is also possible. Cyfluthrin (Bayer Vegetable and Garden Insect Spray) and gamma- or lambda-cyhalothrin (Spectracide Triazicide, Bonide Beetle Killer, Bonide Caterpillar Killer) can be used for control. Cyfluthrin has a 0 day waiting period and lambda-cyhalothrin has a 5-day waiting period on tomatoes. (Ward Upham)